CBD oil is quickly becoming a safe, alternative treatment in the fight against anxiety and depression. But with so many options out there, how will you know what the best brand is? Together, with Cannabis Herald, we’ve taken the guesswork out of the search.

Anxiety and depression impact many people throughout the world. And while prescription medications have been the main go-to in the treatment of these mental health issues, today, more people  are looking toward CBD oil to help support the treatment of these challenging and sometimes debilitating conditions. 

According to the Depression and Bipolar Support Alliance, one in 15 adults suffers from depression every year, while one in six people experiences depression at some time or another during their lives. 

Likewise, the Anxiety and Depression Association of America states that anxiety disorders are the most common mental illness in the United States, affecting 40 million adults aged 18 and older. In fact, the association also states that 264 million people worldwide suffer with anxiety.

Regardless of how severe the symptoms are, anyone who is struggling with or who has struggled with depression or anxiety knows it can feel draining, frustrating, and scary. Today, more people than ever are looking for natural and organic treatments to treat and/or heal depression and anxiety. 

While some patients find success in taking prescription medications for depression and anxiety, others are discovering that CBD oil is also effective in lessening some of depression and anxiety’s troubling and tough symptoms. 

The main reason why CBD oil is so effective for depression and anxiety is because it interacts with the endocannabinoid system, which consists of a group of specialized cell receptors in the brain that helps regulate sleep, appetite, pain, pleasure, mood, and other functions. But more on this a bit later. 

Our article, written in partnership with Cannabis Herald, looks deeply at anxiety and depression and ways that CBD oil can help alleviate the two conditions. We also present to our readers an unbiased look at five CBD brands and explain how CBD functions to help calm and control the symptoms of anxiety and depression. If you don’t want to read all this and want to come to the conclusion on which CBD oil to buy, Visit Fab CBD, It’s the editor’s choice.

How We Compiled This CBD Oil List: 

In order to write this article, we composed a long list of the most popular CBD brands out on the market today. As we kept adding on brands, our list began to grow into something that was both overwhelming and unwieldy. 

Next, we painstakingly researched each brand individually by examining customer reviews, how companies sourced the products, third-party lab reports, and other factors. Because of the length of our list, it took quite some time to get this done. 

Based on the results of our research, we eliminated brands from our list until we were left with a select few that met our strict criteria. Trust us, this was no easy task. 

Finally, we further investigated these brands until we came upon the top five CBD brands for anxiety and depression. It’s also important to mention that our list would not be complete if we didn’t include certified reviews from customers, articles from respected CBD journalists, and reports from niche experts. 

What We Looked For in a CBD Brand: 

In whittling down our extensive list of CBD brands, we closely looked at each company’s products for: 

  • Symptom relief. Most importantly, we wanted to see exactly how effective each brand was at treating anxiety and depression. 
  • How the hemp was sourced
  • The brands’ processing facilities and whether or not FDA guidelines were met. 
  • Whether the company uses broad-spectrum, full-spectrum, or isolate extracts. 
  • The level of THC that is left in the products once they are put out on the market.
  • Whether or not the brand had its products tested by a third-party laboratory and made the test results easily accessible to customers. 
  • The usage and dosage instructions the company gave to its customers. 
  • The company’s reputation and overall customer reviews
  • Whether or not the company offered solid information about CBD such as what CBD is, how CBD works with the body, etc. 

In examining these criteria, we were able to narrow our list down considerably. We present to you our final list of brands for the best CBD oils for anxiety and depression.

Top 5 Best CBD Oil for Anxiety & Depression [Reviews]

1. FAB CBD: Editor’s Choice & Highest Quality

FAB CBD was first founded in 2017, and has always had a strong mission to create a trustworthy, high-quality line of CBD products for any and everybody. 

FAB founder, Josh Delaney, has many years of experience working in the health, nutrition, and fitness sectors.Each and every one of FAB’s products are designed following the highest of standards. 

Currently, FAB CBD produces different strength CBD oils from 150mg to 2400mg in concentration. 

All of FAB’s products are crafted from the finest organic hemp sourced from Colorado, which is then converted into premium extract using CO2 extraction processes that are completely free of solvents. 

What results is an extremely clean extract that is rich in terpenes and essential cannabinoids that give hemp its sought-after health benefits. 


FAB sets itself apart from other companies as the best CBD for anxiety and depression in numerous ways: 

  • Versatile: FAB gives its customers a number of options in its products when it comes to treating anxiety and depression by offering different oil strengths and flavors, a topical cream, and CBD gummies. FAB’s full-spectrum CBD oils come in 300mg, 600mg, 1200mg, and 2400mg in berry, citrus, vanilla, mint, and natural flavors.
  • Organic, Full-Spectrum Hemp: FAB sources its hemp from organic, Colorado-grown hemp in order to make the extract used in all of its products. All FAB hemp is cultivated using state-of-the-art growing, extraction, and cloning equipment/practices in order to guarantee the best raw materials and the highest-quality final products. 
  • Third-Party Lab Testing: Every one of FAB’s products are third-party tested by ProVerde Laboratories. FAB also makes all of its lab reports readily available to its customers on its website. 
  • Money-Back Guarantee: FAB gives each customer a 30-day money-back guarantee on all of its products, which makes the company the best option for anyone trying CBD for the first time. 


  • FAB’s oils come in an array of delicious flavors and in strengths of 300mg, 600mg, 1200mg, and a recently-added 2400mg strength. 
  • Top Rated CBD Oil for anxiety on Dmagazine, Discovermagazine, & HCBT
  • Top-rated CBD Gummies too
  • Excellent customer service. 
  • Fast shipping.
  • Vegan superfood options.
  • Free shipping on all orders over $89.


  • FAB does not ship to the UK or Canada.
  • No autoship or subscription options are available to regular customers. 

==> Buy The Fab CBD Products here

2. Joy Organics: Best Broad Spectrum

Joy Organics was founded by grandmother, mother, and humanitarian Joy Smith, who also used CBD to treat her sleep issues and other health-related problems. 

The company sells oils, soft-gel caps, gummies, pet products, face masks, topical salves, and hemp-infused energy drinks. 

Joy Organics makes broad-spectrum CBD oil tinctures that are THC-Free. Their gluten-free oils are sourced from regulated hemp farms that do not use chemicals. 

The company creates high-quality products and offers CBD oils in four potencies and flavors including 250mg, 500mg, 1000mg, and 1500mg. 

Lab reports are performed by both in-house chemists and a third-party laboratory. All results are published on Joy Organic’s website. 


  • Broad-spectrum CBD: The company’s products are all THC-free and broad-spectrum. Joy Organics removes all of the THC, wax, chlorophyll, and plant pigments from its products by separating and purifying the extracts.
  • CBD-Rich Strains: Joy Organics uses hemp sourced from CBD-rich hemp strains grown in the United States.
  • Variety: CBD tincture flavors derived from natural terpenes and essential oils. 


  • All of Joy Organics’ products are third-party lab tested.
  • The company has a good product selection. 
  • Joy Organic’s products are great for people who want to try THC-free hemp products.
  • The company offers a 30-day money-back guarantee and free shipping.


  • The company does not manufacture the products, and instead has them crafted by Folium Biosciences. 
  • No shipping offered to the UK.
  • Broad-spectrum extracts. 
  • Tinctures only go up to 1500mg strength

3. NuLeaf Naturals: Most Potent Full Spectrum

NuLeaf Naturals produces reliable CBD oils. The company’s products contain all-natural, organic, lab-tested CBD oils and extracts. 

The company’s CBD oil blends contain cannabinoids, terpenes, essential oils, and plant nutrients that are extracted using CO2 extraction methods. 


  • Clean Products: NuLeaf Naturals’ extracts are sourced from organic hemp that was grown by using sustainable farming methods. All products contain zero additives or preservatives. 
  • Lab Testing: The company uses ProVerde Laboratories to third-party lab test all of its products. Test results are made available on the company’s website. 


  • NuLeaf Naturals’ oils come in potencies of 240mg, 725mg, 1450mg, 2425mg, and 4850mg in 5ml, 15ml, 30ml, 50ml, and 200ml sized bottles. 
  • The company ships abroad to over 40 countries. 
  • All products do not contain any additives. 


  • There is no money-back guarantee offered to customers. 
  • There are no flavor options available aside from its natural flavor.
  • NuLeaf Naturals’ products tend to be on the more expensive side.

4. CBDistillery: Best Customer Support Next to Fab CBD

CBDistillery was first founded in 2016 by CBD aficionados from Colorado. The company’s founders discovered that not only was CBD becoming overpriced and out of reach for individuals who needed it, but also the market was getting overrun with inferior products. 

According to the brand’s website, CBDistillery is one of the largest, fastest-growing, and affordable brands in the CBD industry. The company seeks to spread the good word about CBD through talking about the “CBD Movement”on its social media pages.  


  • Clean Hemp: CBDistillery uses non-GMO hemp that is cultivated in Colorado
  • Reliable Testing: The brand uses ProVerde Laboratories to regularly test all of its products. CBDistillery then posts the test results on every one of its products pages. 
  • Certified Brand: CBDistillery is certified through the U.S. Hemp Authority Certification Program. 


  • Third-party lab results are easy for customers to find
  • Cost-saving programs are offered to assist disabled, veterans, and low-income individuals
  • High-quality pure CBD isolate
  • Affordable products
  • Full-spectrum oils
  • Unique product range


  • Product packaging is not eye-catching
  • The brand uses ethanol extraction over the industry-preferred, clean Co2 extraction
  • Documented customer complaints of flimsy oil droppers 

5. Green Roads: Wide Variety

Green Roads was founded in 2013 by Laura Fuentes and Arby Barroso. Fuentes, a licensed compounding pharmacist, wanted to work with Barroso to find a way to use CBD to help calm and heal Barroso’s health issues. The two began formulating CBD products at night and on the weekends. 

Their work soon turned into a partnership with Danny Perdeck and Jimmy Tundidor. With this new collaboration, CBDistillery quickly began to sell its products in over 10,000 retail locations. The brand’s mission is to help every individual find the healthiest version of themselves.  


  • Educational Resources: Green Roads created  “CBD University” on its website to educate customers about CBD.
  • Customer Information: Since CBD can be overwhelming and confusing, Green Roads provides its customers with a wealth of information about CBD on its website and even offers customers a “Beginner’s Bundle” that contains its top-selling products. 
  • Lab Results: The brand makes all of its lab results readily available to all of its customers and believes strongly in the importance of transparency.  


  • Large product line
  • Free shipping on orders over $100
  • Affordable prices
  • Discounts for veterans and first responders
  • Third-party lab testing
  • 30-day money-back guarantee


  • Oil taste tends to be on the stronger side when compared to other brands
  • No full-spectrum or isolate products offered
  • Some products, like CBDistillery’s gummies, contain artificial colors and ingredients
  • No variety in CBD drinks 

Even though there is a wide variety of CBD brands on the market today, not all of these brands are created equal.

When using CBD oil for anxiety and depression, it’s best to know:

  • Where the company sources its hemp. Cannabis that is grown in Asia and Europe doesn’t have to pass the same standards as hemp that is cultivated in the United States.
  • How much THC is in a product. By law, all products sold in the United States must contain less than 0.3 percent THC.
  • Whether the product is full-spectrum, broad-spectrum, or a CBD isolate. Products that are full-spectrum are considered to be the best because they contain the most beneficial terpenes, cannabinoids, and other hemp components. Because of this, full-spectrum CBD products are more effective due to their entourage effect on the body.
  • Other ingredients that a company uses in its products. CBD tinctures, edibles, and cosmedics sometimes contain preservatives and flavoring agents. Always purchase products that are crafted from all-natural, organic ingredients.
  • Third-party lab test results. Regardless of what brand of CBD you buy, always double check to see that all third-party lab test results are easily accessible and available to you.

What to Consider Before Buying CBD Oil for Anxiety?

Even though there is a wide variety of CBD brands on the market today, not all of these brands are created equal. 

When using CBD oil for anxiety and depression, it’s best to know: 

  • Where the company sources its hemp. Cannabis that is grown in Asia and Europe doesn’t have to pass the same standards as hemp that is cultivated in the United States. 
  • How much THC is in a product. By law, all products sold in the United States must contain less than 0.3 percent THC. 
  • Whether the product is full-spectrum, broad-spectrum, or a CBD isolate. Products that are full-spectrum are considered to be the best because they contain the most beneficial terpenes, cannabinoids, and other hemp components. Because of this, full-spectrum CBD products are more effective due to their entourage effect on the body. 
  • Other ingredients that a company uses in its products. CBD tinctures, edibles, and cosmedics sometimes contain preservatives and flavoring agents. Always purchase products that are crafted from all-natural, organic ingredients. 
  • Third-party lab test results. Regardless of what brand of CBD you buy, always double check to see that all third-party lab test results are easily accessible and available to you. 

Using CBD to Tackle Anxiety and Depression

CBD has many wonderful health benefits, and regularly taking CBD can alleviate the difficult symptoms associated with anxiety and depression. 

Some benefits of taking CBD are as follows: 

  • CBD helps the body regulate the stress response. 
  • CBD activates the hydroxy tryptamine serotonin receptor, which in turn creates an anti-anxiety effect. 
  • Studies show that CBD is effective in treating brain and emotional disorders such as anxiety, depression, psychosis, and multiple sclerosis among other conditions. 
  • Researchers are still investigating CBD’s positive effect on post-traumatic stress disorder, social anxiety disorder, panic attacks, depression, and anxiety. 

CBD improves the symptoms of depression and anxiety by reducing stress levels, elevating moods, and bettering an individual’s overall ability to handle stress. 

Even though CBD is not likely to cure depression or anxiety, it will greatly improve conditions and symptoms. In using CBD to manage anxiety and depression, you are creating a better quality of life for yourself.

The Mechanics of the Endocannabinoid System

The endocannabinoid system, or ECS, is a complex system within the body that helps to regulate various functions within the body like sleep, appetite, mood, memory, digestion, fertility, reproduction, and others. 

In order to make this happen, the endocannabinoid system has three main components of enzymes, receptors, and endocannabinoids, that all work together to create a state of balance, or homeostasis, within the body. 

  • Endocannabinoids, which are very much the same as cannabinoids, are molecules that the body makes that help keep the body’s functions running without issue. 
  • Receptors, endocannabinoid receptors to be exact, are located within the body. In order for the endocannabinoid system to kick into gear, the endocannabinoids must bind to the receptors. The main receptors are CB1 and CB2 receptors. While CB1 receptors sit within the central nervous system, CB2 receptors are found in the peripheral nervous system.
  • Enzymes break down endocannabinoids after they’ve completed their mission. 

The endocannabinoid system is very complicated, and more research still needs to be done on it, however, scientists do know that the system helps with: 

  • Metabolism
  • Digestion
  • Appetite
  • Sleep
  • Learning
  • Memory
  • Chronic pain
  • Motor control
  • Inflammation
  • Mood – to help with anxiety and depression
  • Skin and nerve health
  • Reproduction function
  • Muscle formation
  • Liver functioning
  • Bone growth and remodeling
  • Functioning of the cardiovascular system

CBD Oil’s Impact on Anxiety and Depression

The neurotransmitter serotonin is important in the proper regulation of moods and functioning of mental health. It’s believed that low serotonin levels are responsible for causing both anxiety and depression. 

Today, scientific studies are proving that CBD oil can decrease anxiety. And since all full-spectrum CBD oils are legally required to have less than 0.3% THC, not only is it legal to purchase hemp-derived CBD oils within the United States, but you also will not get “high” from it. This means that you can safely help your anxiety and depression without any worry about getting high. 

In fact, a 2019 study found that CBD oil is better tolerated than prescription anti-anxiety medications like benzodiazepines which can be dangerously addictive and have a history of being abused. In fact, that same study also found that CBD showed great promise when it came to overall anxiety reduction. 

When someone takes CBD oil, it’s best to hold the oil under the tongue, or sublingually. This way, the CBD can be best absorbed by the mucous membranes so that it can quickly enter into the bloodstream to take effect.

CBD oil is a great option for anyone who has trouble swallowing capsules or who cannot take edibles due to issues such as diabetes or sugar sensitivities. If people are concerned about the strength of CBD oil’s taste, the good news is that many oils, like FAB CBD’s full-spectrum oils,  are infused with natural flavors such as peppermint, vanilla, berry, or citrus. 

Does CBD Oil Have Any Side Effects?

CBD is well-tolerated by many individuals. In fact, studies have shown that people report very few side effects from using CBD. Some of the very minor side effects that were reported, however, were: 

  • Diarrhea
  • Fatigue
  • Changes in appetite
  • Sleepiness

A review of 132 scientific studies conducted in 2011 found that CBD has both very limited side effects and does not have any major negative impacts on the functioning of body systems. For example, the study discovered that CBD did not negatively affect blood pressure, body temperature, motor functions, gastrointestinal movement, heart rate, or psychological functioning. 

While the side effects of CBD are mild, if you are on prescription or over-the-counter medications, have a serious existing medical condition, or are trying to get pregnant, then you should first consult with your physician before beginning a CBD regimen. 

In order to minimize the risks for side effects, it’s best to begin taking the smallest dose possible that will still provide you with relief from anxiety or depression. Likewise, if you are on prescription medication, you should first consult your doctor before taking CBD as it can interfere with the metabolism of some medications. 

The Grapefruit Warning

A great rule to follow when it comes to taking CBD oil along with prescription or over-the-counter medications is to go by the grapefruit warning. In other words, if your medication has a grapefruit warning on the label, then it’s best to avoid taking CBD while on that medication. 

The grapefruit warning on medication labels states that eating grapefruit or drinking grapefruit juice should be avoided while taking the medication. The simple act of consuming grapefruit while on the medication can bring out elevated levels of the drug in the blood as well as adverse side effects, or a potential overdose. 

Currently, there are over 85 medications that negatively interact with grapefruit and other related citrus fruits. These fruits, much like CBD, inhibit specific bodily enzymes, which in turn causes medications to be metabolized at a dangerously slower rate. If you see the grapefruit warning label on your prescription or over-the-counter medication, then you might want to speak with your primary care physician before trying CBD. 

Some common medications that carry the grapefruit warning are: 

  • Blood thinners
  • Cholesterol medications 
  • Antihistamines
  • Antibiotics
  • Antimicrobials
  • Immunosuppressants
  • Pain medications
  • Heart rhythm medications
  • Blood pressure medications 
  • Prostate medications
  • Gastrointestinal medications
  • Anti-seizure medications
  • Corticosteroids

Even though these medications may potentially interact with CBD, it’s best to consult with your doctor to see if there is a possibility of safely using CBD while on these medications. If you received a doctor’s approval to try CBD while on these types of medications, it’s best to regularly monitor any changes that may occur in the way your medication is affecting you or in how you are feeling while taking the CBD. 

Full-Spectrum Oils and the Endocannabinoid System

Full-spectrum CBD oils have THC, CBD, and many other beneficial cannabinoids and terpenes in them. THC, or tetrahydrocannabinol, is the compound found within cannabis that is responsible for those feel-good, euphoric highs. When THC enters the body through a full-spectrum oil, the compound binds with endocannabinoid receptors to help reduce pain and increase feelings of hunger. 

CBD, or cannabidiol, another compound found within the cannabis plant, will not make you feel high and typically does not trigger any negative side effects. Even though CBD does not bind to the endocannabinoid receptors in the same way that THC does, it still works with the endocannabinoid system to stop the breaking down of endocannabinoids. This simple action of CBD with the ECS enables endocannabinoids to have a stronger impact within the body. 

CBD Dosage for Anxiety?

Just like with any supplement or medicine, proper dosing of CBD is extremely important. 

In figuring out what the best dosage of CBD for your body is, it’s best to remember that everyone is different. Therefore, a dosage that works for one person may not work the same for another. 

Mid-range doses of CBD tend to work better than lower or higher doses of CBD. 

For those just beginning to use CBD, it’s best to begin by taking a daily 5mg dose once a day. Low and slow is the best way to go when it comes to beginners doses for CBD oil. 

Take the 5mg dose for about one week before gradually stepping up the dosage if you feel you need to. Always check in with your body before increasing your dose. 

If you do need to increase your dose, remember to keep using the same dose for about one week before increasing to a new dose, as the body needs time to adjust to the change. 

You should never worry that you are taking too much CBD, as it is not possible to overdose on it. A good rule of thumb is to start with a ½ dropper of  FAB CBD’s 300mg tincture once per day. This will roughly equal 5mg of CBD. 

Next, reassess how you are feeling after one week to see if you are achieving your desired results, then, if need be, increase the dose to a ½ dropper twice a day. This increase will then work out to about 10mg of CBD. 

Final Thoughts: Which CBD Brand is Best for Anxiety?

If you suffer from anxiety or depression, then CBD will be able to offer you fast, effective relief without all of the negative side effects associated with many prescription medications that can take weeks or even months to take effect. Likewise, CBD is not addictive like many prescription anti-anxiety and antidepressant medications can be. 

Unlike prescription anxiety and depression medications, CBD is completely safe, natural, and non-toxic. In fact, CBD is documented as having very few side effects. Moreover, the side effects that are associated with it, such as sleepiness, diarrhea, nausea, low blood pressure, dizziness, and mood changes, are mild at best. 

Whether you suffer from anxiety or depression, consider trying some of the products talked about in this article. All of FAB CBD’s products provide safe, reliable relief for everyone struggling with anxiety or depression. The Cannabis Radar recently added them as #1 CBD brand for anxiety on their blog.

There are plenty of verified industry and customer reviews that confirm that FAB CBD full-spectrum CBD oils are at the top of the list when it comes to quality CBD oils to help calm and manage anxiety and depression. Another notable brand, Joy Organics, comes in as a strong and respectable second.

But whichever brand you end up choosing, it’s best to first take the time and do the research into what CBD is, how it can help, and which brands might be best for you at tackling your issues of anxiety or depression. A great first place to begin is by looking at the brands presented before you in this article. 

If you have any further pressing questions about CBD and how it works to alleviate depression and anxiety and whether or not CBD could be an effective treatment for you, then it’s best to schedule an appointment with your primary care doctor or specialist.