The Bioavailability of Different THC-O Products/Methods 

THC-O, a synthetic cannabinoid that is said to produce effects up to three times as potent as standard THC, has continued to grow in popularity. As more products fill the market, you might be wondering what is the best way to consume THC-O so that you get the maximum effect? The answer to that will depend on the method of ingestion. 

What is THC-O?

THC-O is the newest cannabinoid, synthesized in a lab using various extraction methods. Although it is similar molecularly to THC, it does not occur naturally in marijuana like Delta 8 and Delta-9. 

After synthesis is complete, what is left behind is an extremely bioavailable form of Delta 9 THC, one that must be metabolized for the effects to begin. 

What Is Bioavailability?

In short, bioavailability is the rate and extent to which a drug/substance enters the circulatory system. Bioavailability is often influenced by the method of ingestion, especially in the case of THC.

With other THC cannabinoids like Delta-8 and Delta-9, whether you choose to vape, smoke, or eat your doses, the end result is by and by, largely the same. This is not the case for THC-O.

What is the Best Way to Consume THC-O?

Although little confirmed scientific information about THC-O is available, as it is still a relatively new cannabinoid, general consensus discourages the smoking/vaping of THC-O. 

It has been suggested that THC-O is a prodrug, a drug that must be metabolized in order to take effect. Choosing to smoke or vape THC-O could cost you some potency and longevity of the effects while choosing to eat the cannabinoid in the form of an edible has been shown to be highly effective. 

The rate of bioavailability is thought to be much higher when eaten, with users reporting the most intense highs when taken as an edible. 

Benefits of THC-O and High Potency 

THC-O could prove beneficial to those who, either by recreational or medical use, have built up an extreme tolerance to THC. Tolerance begins to build every time you consume THC, and eventually, the effects will begin to dwindle. 

The high bioavailability of THC-O and extreme potency could help manage a high tolerance, as even if you are a veteran smoker, you are likely to be taken aback by how intense your highs will be.

This has the potential to be especially useful for those chronic users treating ailments with medical marijuana, who are at risk for higher tolerance. Higher tolerance, in this case, would mean lessened medicinal benefits, which could be harmful to someone using THC to manage pain or disease. 


There is strong evidence that implies that the bioavailability of THC-O is increased when ingested orally, as opposed to smoking/vaping. Bioavailability is the measure of a substance’s rate and extent as it enters the body. 

THC-O is still new, and more information is likely to come out, so be sure to stay informed on all the latest news about THC-O. New developments are sure to arise in regards to the cannabinoid’s potential benefits for heavy users of THC, whose tolerance has peaked. CannAid offers some of the best products in wellness, including THC-O — check out their online selection and see what all the buzz is about, no pun intended!

LA Weekly