Best Lions Mane Supplements In 2023

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A lot has changed in the supplement industry over the last few years. Many new hot supplements, botanicals, and herbs are becoming mainstream. Among the most popular is lions mane mushroom. Lions Mane supplements offer a range of health benefits, most notably their use as one of the best nootropics

Whether you’re looking to improve cognitive performance, reduce anxiety and depression, or just want a natural boost in your energy levels, these supplements can be incredibly helpful. So, what are the best lion’s mane supplements available in 2023?

We’ve rounded up some of the top-rated lions mane supplements on the market today. These products are made with high-quality ingredients and have been thoroughly tested to ensure they are safe and effective.

The table below shows the top 5 Lion’s Mane supplement brands of 2023 that we’ll review in this article.

Brand NameProduct NameType of SupplementDosage
BATCHBrain Boost Mushroom GummiesGummies – Lion’s Mane, Cordyceps, and Reishi Mushrooms1-2 gummies
Four SigmaticLion’s Mane ElixirPowderOne packet per day
Fungi PerfectiLion’s Mane CapsulesCapsules2 capsules once per day
Real MushroomsOrganic Lions Mane Extract CapsulesCapsules2 capsules per day
Nootropics DepotLion’s Mane Mushroom Extract PowderPowder1 capsule 1-2 times a day

Note: The prices listed are based on the recommended retail price (RRP) at the time of writing, and may vary depending on the retailer and location.

Each of these supplements has been thoroughly researched by our team and is backed by science to provide you with the most health benefits. We’ll go through each one in detail, so you can decide which product is best for your needs.

For those who don’t know what Lion’s Mane Mushroom is, we’ll start off with a brief overview of the supplement.

What is Lions Mane Mushroom?

Lion’s Mane Mushroom, also known as Hericium erinaceus, is a unique and increasingly popular type of mushroom with a long history of use in traditional medicine. It is native to Asia, Europe, and North America and has been consumed for centuries due to its potential health benefits.

In recent years, Lion’s Mane Mushroom has gained more widespread recognition for its medicinal properties and has become a popular ingredient in various health supplements and food products. 

The mushroom has a distinctive appearance, with long, white, shaggy spines that resemble a lion’s mane, hence its name. It typically grows on trees, especially hardwoods such as oak and maple.

In terms of nutritional content, Lion’s Mane Mushroom is rich in protein, fiber, vitamins, and minerals, including potassium, magnesium, and zinc. It is also low in calories and carbohydrates, making it a healthy addition to one’s diet.

One of the most notable features of Lion’s Mane Mushroom is its potential medicinal properties. It contains several active compounds, including polysaccharides, beta-glucans, and erinacines, which have been shown to have anti-inflammatory, antioxidant, and neuroprotective effects [1].

Some studies suggest that Lion’s Mane Mushroom may be effective in Attention Deficit Hyperactivity Disorder (ADHD), anxiety, depression, Alzheimer’s disease, and Parkinson’s disease. It may also help with cognitive function and memory. We’ll discuss this further later on.

In addition to its medicinal properties, this medicinal medicine is also known for its unique taste and texture, making it a popular culinary ingredient. It can be consumed raw, cooked, or in various forms, such as powder, tincture, extract, or capsule.

Enough background information – let’s now dive into the top 5 Lion’s Mane supplements of 2023. Here is more information on where you can find lions mane for sale

5 Best Lions Mane Supplements In 2023 – Product Reviews

Here’s our roundup of the top 5 Lions Mane supplements on the market today:

1. BATCH Brain Boost Mushroom Gummies

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  • Price: $59.99 or $44.99 with a subscription
  • Key ingredients: 300mg organic lion’s mane extract, 100mg organic cordyceps extract, and 10mg organic reishi mushroom extract
  • Benefits: Supports cognitive function, memory, focus, and concentration
  • Certifications: Non-GMO, USDA-certified organic, and vegan

On top of our list and our favorite is Brain Boost Mushroom Gummies by BATCH, a company that gained immense popularity for its unique and delicious CBD-infused products. The Wisconsin-based company recently expanded its product line to include a range of mushroom-based health supplements, including Lion’s Mane mushroom gummies.

The gummies are made with a blend of three functional mushrooms (Lion’s Mane,Reshi, and Cordyceps) and botanicals that are specifically formulated to support brain function and memory. They also contain verified levels of active compounds, including beta-glucans and polysaccharides, that are known to have neuroprotective and cognitive-enhancing effects.

To test the product, our team took one gummy daily for four weeks. The gummies were easy to take and had a pleasant taste, which was surprisingly different from the usual mushroom flavor. We experienced increased focus and mental clarity after the first week, and this effect seemed to increase over time. We also noticed an improvement in our overall mood and energy levels.

For CBD enthusiasts, Brain Boost Mushroom Gummies are a great addition to your daily regimen. Combining CBD with Lion’s Mane has been shown to have powerful synergistic effects, making this product an excellent choice for those looking for a holistic approach to mental health.

Key Features

  • Subscribe and save 25%
  • 30-day money-back guarantee
  • Dual-extracted 8:1 mushroom extracts
  • Third-party lab tested
  • No psychedelic effects
  • Made with natural substrate
  • 100% fruiting bodies

2. Four Sigmatic Lion’s Mane Elixir

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  • Key ingredients: Lions Mane mushroom extract, Rhodiola rosea root extract, organic field mint extract
  • Benefits: Brain-boosting, energy-enhancing, cognitive clarity
  • Certifications: None

Start your morning with Four Sigmatic’s Lion’s Mane Elixir, a brain-boosting elixir that gives you the ultimate edge regarding productivity and creativity. This unique blend of Lions Mane mushroom extract, Rhodiola rosea root extract, and organic field mint extract provide a caffeine-free energy and focus boost that can help you tackle the day with clarity.

Each serving contains 3,000mg of Lions Mane mushroom extract, providing you with all the cognitive support your brain needs. It also contains Rhodiola rosea root extract, which has been used for centuries to support mental performance and reduce stress [2]. And to top it off, it has a hint of organic field mint extract for a refreshing and pleasant taste.

Our team of experts has given this elixir rave reviews for its potency and effectiveness. But one thing to note is that it’s not certified as kosher or vegan, so if you’re looking for those certifications, you may have to look elsewhere.

All in all, Lion’s Mane Elixir from Four Sigmatic is a great choice for anyone looking for a natural and effective way to boost their mental performance. Plus, it’s conveniently packaged in single-serve packets, so you can take it with you anywhere.

Key Features

  • Caffeine-free 
  • Rigorously tested for potency and effectiveness 
  • Organic ingredients 
  • Plant-based
  • 120-day money-back guarantee
  • Single-serve packets for easy portability

3. Host Defense Lion’s Mane Capsules

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  • Key ingredients: Certified Organic mycelium and fruiting bodies of Lion’s Mane mushrooms, organic pullulan (a safe and natural capsule material), and myceliated brown rice
  • Benefits: Supports cognitive performance, memory, and healthy nerve cells
  • Certifications: Certified Organic, Non-GMO, Gluten-free, and Vegan

For a more traditional option, try Host Defense Lion’s Mane Capsules. This all-natural supplement is made with premium lion’s mane mushrooms that have been cultivated and then freeze-dried to preserve their natural properties. The capsules contain no fillers, additives, or preservatives, making them a great choice for those who prefer an all-natural approach to supplementation.

Many of the active compounds found in lion’s mane mushrooms have been linked to cognitive benefits, such as increased focus and mental clarity. Host Defense Lion’s Mane Capsules are also rich in polysaccharides, which have been shown to support the immune system. 

When we think of the phrase “brain food,” Host Defense Lion’s Mane Capsules are the perfect example. This supplement can give your brain the essential nutrition to stay sharp and perform at its best.

Additionally, Host Defense Lion’s Mane Capsules are easy to take – just pop one (or two!) in your mouth, and you’re good to go. No need to worry about measuring out portions or trying to mix it with a drink – these capsules are as simple and easy as they come.

While you can’t expect to become a genius overnight, Host Defense Lion’s Mane Capsules are a great way to give your brain the extra boost it needs. Some of our reviewers didn’t love the taste, but with its cognitive benefits, that’s a small price to pay!

Key Features

  • Available in 30, 60, and 120 capsules
  • 90-day satisfaction guarantee
  • All natural ingredients, no fillers or preservatives
  • Easy to take capsules for on-the-go convenience
  • Fast-acting with real cognitive benefits

4. Real Mushrooms Organic Lion’s Mane Capsules

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  • Key ingredients: Organic Lion’s Mane mushroom, hypromellose (capsule), microcrystalline cellulose, silicon dioxide, and also may contain trace amounts of stearic acid
  • Benefits: Supports brain and cognitive function, boosts energy levels, and enhances mental clarity. Also supports heart health, digestion, and the immune system
  • Certifications: NSF-certified facility, gluten-free, non-GMO, vegan

Real Mushrooms Organic Lion’s Mane Capsules provide all the benefits of the top-shelf lion’s mane mushroom extract without any added starch, mycelium, or grain. Many reviewers laud its potency, quality, and effectiveness – not to mention its affordability.

According to Real Mushrooms, their lion’s mane extract is made with certified organic mushrooms and hot water extraction. This method allows them to retain all the non-water soluble components of the mushroom, making their supplements more potent than many other brands.

Each capsule contains 500mg of lion’s mane extract and guaranteed levels of at least 30% Beta-glucans. Beta-glucans are polysaccharides that have been linked to improved cognitive function, hence the reason why our reviewers appreciate this supplement’s potency so much.

Real Mushrooms Organic Lion’s Mane Capsules come in two size options – 120 and 300 capsules. Both sizes come in plastic containers to ensure freshness and a longer shelf life. Moreover, all of the Real Mushrooms’ products are verified for quality by accredited third-party labs and made in an NSF (National Sanitation Foundation)-certified facility. This detail is essential for those who are looking for a safe, reliable supplement to take. 

Key Features

  • Certified organic mushrooms 
  • Hot water extracted
  • Not less than 30% Beta-glucans 
  • 120 and 300 capsules size options 
  • Third-party lab tested for quality
  • NSF-certified manufacturing facility in the USA 
  • Zero added starch, mycelium, or grain content

5. Nootropics Depot Lion’s Mane Mushroom Extract Powder

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  • Key ingredients: 100% pure Lion’s Mane extract powder, standardized to 15% β-glucans
  • Benefits:
  • Certifications:

Nootropics Depot’s Lion’s Mane Mushroom Extract Powder made the cut for being one of the best supplements in this list for a few reasons. First, this company sources its ingredients from the most pristine environments to ensure that all of its supplements are up to quality standards.

Second, Nootropics Depot control tests all of its ingredients to verify potency and quality. In the case of this particular supplement, it is standardized to 15% β-glucans, which is the active ingredient in lion’s mane that has been linked to improved cognitive function.

Third, the company has its own research and development lab and follows Good Manufacturing Practices (GMP) guidelines. These practices guarantee that the supplements are free of any impurities, contaminants, or allergens.

Finally, Nootropics Depot is in this business to stay. They are always designing and developing new supplements and expanding their product line. This shows their commitment to the industry, and it’s something we appreciate and take into consideration when looking for a reliable lion’s mane supplement.

Key Features

  • 8:1 extract (Hericium erinaceus)
  • Available in 30 and 60g size options
  • Standardized to 15% β-glucans
  • Control tested for potency and quality
  • Own research and development lab
  • Follows Good Manufacturing Practices (GMP) guidelines
  • Free shipping on domestic orders over $50 USD
  • Free Standard Worldwide Mailing on orders over $200 USD
  • Made in the USA

Benefits of Lions Mane Supplements

Lion’s mane supplements can provide a variety of cognitive benefits, from improved memory to enhanced focus and creativity. Here are some of the most commonly reported benefits associated with these supplements:

Focus & Concentration

One of the most commonly reported benefits of lion’s mane supplements is improved focus and concentration. Some research suggests that compounds in lion’s mane may stimulate the growth of new brain cells and enhance the production of nerve growth factors [3], leading to better communication between neurons and improved cognitive function overall.

Additionally, the beta-glucans found in lion’s mane can help promote higher levels of acetylcholine. This neurotransmitter plays a key role in memory formation and concentration, so increased levels in the brain can lead to better focus.


Lion’s mane supplements may also have benefits for memory. In some studies, lion’s mane extract has been shown to improve cognitive function in people with mild cognitive impairment and may even have potential as a treatment for Alzheimer’s disease [4]. This could be due in part to the increase in nerve growth factors that lion’s mane may stimulate, which could help protect and repair neurons in the brain.


enhancing problem-solving skills and increasing creativity. These effects may be due in part to the role that NGF and BDNF play in promoting the growth and survival of brain cells, as well as the ability of the lion’s mane to support healthy inflammation levels in the brain.

Mood and Energy

Finally, some people have reported that lion’s mane supplements have positive effects on mood and energy levels. While the research on this topic is limited, some studies have suggested that lion’s mane extract could have antidepressant and anti-anxiety effects. Additionally, lion’s mane may help to reduce inflammation and oxidative stress, which can lead to improved mental energy. Here is more information and product reviews for the best functional mushrooms for mood, energy, and more.

Bottom Line

Lion’s mane supplements can have various cognitive benefits, from increased focus and concentration to enhanced memory formation and creative problem-solving skills. While the research is still limited, many users have reported positive results after taking lion’s mane supplements. More broadly, mushroom supplements are a great option for people searching for a natural way to improve their health. 

Of the five products we’ve reviewed here, Brain Boost Mushroom Gummies by BATCH  is our top pick. It contains an 8:1 extract of lion’s mane, which is a potent concentration usually only found in more costly supplements. It’s also one of the few products to include the dual extraction process, which maximizes the bioavailability of its active ingredients. 

No matter what you choose, always double-check the label carefully to make sure you’re getting exactly what you need. And if you’re in doubt or have any questions, consult a healthcare professional before taking these or any other supplements. Happy supplementation!

Lions Mane FAQs?

Is Lions Mane Safe?

Yes, Lions Mane is considered safe when taken in moderate doses. It is a natural mushroom with few reported side effects and no known significant adverse reactions. Lions Mane is generally well-tolerated and is safe to take on a regular basis, as long as it is taken in the recommended doses.

Are There Any Side Effects of Lion’s Mane Supplements?

Some of the reported side effects of Lion’s Mane supplements include mild gastrointestinal symptoms such as bloating, diarrhea, and nausea. Additionally, some individuals may experience a skin rash, itching, or headaches. Most of these side effects are generally mild and short-lived.

Can Lions Mane Supplements Interact With Any Other Medications?

Yes, Lion’s Mane supplements may potentially interact with medications that affect blood clotting, such as anticoagulants or antiplatelet drugs, as there is some evidence that Lion’s Mane may also have a blood-thinning effect. If you are under any medication or have a chronic medical condition, it is best to consult your healthcare professional before taking Lion’s Mane supplements.

Can I Take Lions Mane Supplements if I Am Pregnant or Nursing?

No, taking any dietary supplement while pregnant or nursing is not recommended. This includes Lion’s Mane supplements, as there is insufficient evidence regarding their safety for pregnant and nursing women. If you are pregnant or nursing, always consult your care provider before taking any supplements.

How Long Does It Take for Lions Mane Supplements to Work?

The time it takes for Lion’s Mane supplements to work can vary depending on several factors, such as the dosage, the individual’s health condition, and the quality of the supplement. Generally, Lion’s Mane supplements may take a few weeks to several months before noticeable effects occur.

Some people report feeling improvements in their cognitive function, memory, and overall mood within a few days or weeks of taking Lion’s Mane supplements. Others may not notice any significant changes for several weeks or even months. It is important to remember that Lion’s Mane supplements are not a quick fix, and the effects may occur gradually.

What’s a Proper Dose of Lions Mane?

The recommended dosage for Lion’s Mane supplements varies depending on the product and the individual taking it. Generally, starting with a lower dosage of 250 mg is suggested and gradually increasing to 750 mg daily. Following the dosage instructions on the supplement’s label is also important, as some products may require a lower or higher dose.


  1. Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. Journal of Agricultural and Food Chemistry, 63(32), 7108–7123.
  2. Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention. Current Pharmacology Reports, 3(6), 384–395.
  3. Lai, P., Naidu, M., Sabaratnam, V., Wong, K., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.
  4. Rodriguez, M. N., & Lippi, S. L. P. (2022). Lion’s Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model. Behavioral Sciences, 12(7), 235.

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