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Barbara DeSantis' Boulder House has become a fixture among young weekend warriors in need of serious relaxing and otherworldly exploration. Beyond the reach of the smog and behind a shield of thousands of Joshua trees, DeSantis' four-bedroom vacation home (it sleeps up to 14 and starts at $695 per night) is carved out of desert boulders the size of Volkswagens. The spectacular exterior looks like a Flintstones bunker and every inch of the interior has been meticulously curated with trippy art and colorful Mexican fabrics. Each room is unique: There are salmon- and canary-hued suites and a boulder-walled bedroom with a bed on a rock. The 15-acre grounds of pristine desert scrub come complete with a pool, hot tub and grill, offering the perfect balance between splurge-worthy luxury and natural ruggedness. Expand your mind while roaming the desert — or just kick back in the hot tub and admire the scenery.

53533 Coyote Road, Yucca Valley, 92284. (310) 994-7101, boulderhousejoshuatree.com.