Best CBD Pain Creams for 2022: A Complete Guide

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CBD has emerged as one of the most promising methods for combatting pain over the last few years. If you’re looking for some non-prescription relief from your aches and pains, you’ll find hundreds of options online. From CBD pills, oils to edibles, the choices are many, and they all help fight pain. However, for joint or muscle pain, a topical solution like CBD cream can be particularly helpful.

The endless varieties of CBD pain creams available online can overwhelm anyone. In the wake of the CBD boom, many brands have cropped up to capitalize on this trend. But only a few products make the cut when it comes to quality and value.

It can be difficult to research all available brands and their pros and cons. How do you determine which brand is worth your money? We’ve spent many hours doing the hard work to make your shopping just a bit easier.

3 Best CBD Pain Creams in 2022

The most common way manufacturers make CBD pain cream is by adding CBD to hemp seed oil, which is then used as an ingredient in creams and lotions. CBD is one of the most beneficial compounds found in the hemp plant. CBD doesn’t cause a high that’s typically associated with THC. CBD is renowned for its pain-relieving, anti-anxiety, and anti-inflammatory effects.

An effective CBD pain cream can make a big difference in your life. However, when looking for a product, doing your research is imperative. There are hundreds of dubious brands being sold online, and some of them can do more harm than good.

To give you an easy summary of the best available products, we’ve combed through the market for hours. Here are 3 of the very best CBD pain cream brands you can buy in 2022:

CBDPure Muscle & Joint Formula (500 mg)

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CBDPure is a well-known brand that has been around since 2018. It’s rightfully known as an industry leader for offering potent, science-backed products at reasonable prices. CBDPure Muscle & Joint Formula (500 mg) is their proprietary formula which is designed to provide targeted comfort within 2-3 minutes from being applied. Their website says that only a pea-sized serving applied to the affected area works well.

CBDPure’s formula is designed for maximum efficient absorption. They source their full-spectrum CBD from homegrown hemp on a family farms in Washington. Other ingredients include menthol, which is known for its anti-inflammatory effects, and white willow bark, also known as “Nature’s aspirin”. They use independent 3rd party testing to ensure that only the best quality ingredients make the cut, and provide those results to the public.

CBDPure takes safety seriously and follows strict cGMP compliant manufacturing guidelines. All these efforts underline CBDPure’s trustworthy and reliable product quality. It also offers a generous and unconditional 90-day money-back guarantee which means your purchase is virtually risk-free.

CBDPure Muscle & Joint Formula (500 mg) is available at $39.99 in the form of an easy-to-use tube. When we consider the many factors in its favor, CBDPure is our top pick among all other CBD products.

Verdict: Top Pick

Price: $39.99

Guarantee: 90 Days


Populum’s Cold Therapy Hemp Rub (100 mg)

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Populum has been on the CBD scene for quite a while now and has evolved into a popular brand for high-quality CBD products. Their Cold Therapy Hemp Rub is a fast-acting CBD & aloe-infused cooling relief cream for your muscles and joints.They offer a CBD concentration guarantee and claim that their products are triple-tested for purity and potency.

Populum’s #1 mantra is to create clean and natural products that you can trust. For this product, they only use  plant-based ingredients and no parabens. Their unique formulation of CBD, chamomile, arnica, and aloe is designed to quickly penetrate muscles and provide relief for muscle and joints.

Populum’s products use a full-spectrum hemp extract. They use scientifically-tested extracts that contain healthy concentrations of CBD, CBN, CBD, and terpenes. Their formulation contains chamomile, which reduces stress and soothes skin. It also contains aloe vera, which provides cooling relief and is known for its moisturizing and healing benefits. Finally, there’s arnica, which is renowned for its anti-bruising and antimicrobial properties. Purely from a perspective of ingredients, this product really shines!

Populum uses third-party lab tests to check for more than 80 total harmful compounds. The website says that test results for the Cold Therapy Hemp Rub show no traces of: pesticides, microbials, mycotoxins, or heavy Metals. The product is vegan, non-GMO, and made in the USA.

Populum’s Cold Therapy Hemp Rub is priced at $45.00 for a one-time purchase or $36 if you buy a monthly subscription. This product is a solid pick considering all its positive qualities.

Verdict: Cost-effective choice

Price: $45

Guarantee: 30 Days


XWERKS Rub (500 mg)

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Xwerks is a new entrant in the market, but it has made a splash with its promising range of CBD products. Their hemp is organically grown, harvested, and processed in Colorado. XWERKS Rub is a full spectrum CBD cream designed to relieve sore and achy muscles and joints. It’s a blend of plant-based compounds, including 500mg of Cannabidiol (CBD), Willow Bark & Menthol. 

Their website claims that Xwerks CBD products not only contain CBD but the entire array of phytocannabinoids found in hemp. This helps create the ‘entourage effect’, which maximizes many of the benefits associated with hemp products. They also use the ‘supercritical C02 extraction’ to process hemp plants, which yields the cleanest, solvent-free hemp oil leaving the vital phytocannabinoids intact.

The website says that you will typically feel results in 2-3 minutes and that continued use over time is likely to improve results as well. At $49 per tube, this looks like an impressive product.

Verdict: Promising Choice

Price: $49.00

Guarantee: Not Specified


How Do CBD Creams Compare To CBD Oils?

When using CBD oil or tincture, the usual method is to place a few drops under the tongue. This method of delivery is usually effective for treating anxiety or promoting deep sleep.

A CBD topical is any CBD-infused lotion, cream, or salve that can be applied directly to the skin. For relief against joint and muscle pain, CBD creams are often quicker and more effective. CBD creams and lotions typically include additional ingredients to enhance an analgesic, anti-inflammatory effect. 

Even though there are many ways to try CBD, a topical may be your best bet if you need to treat skin issues or relieve aches and pains.

How Is CBD Different From THC?

CBD (cannabidiol) and THC (tetrahydrocannabinol) are the most common cannabinoids commonly found in hemp products.

THC and CBD are naturally present in both marijuana and hemp. Marijuana contains much more THC than hemp, while hemp tends to be high in CBD.

THC is the main psychoactive compound in cannabis. It’s the well-known chemical that makes people feel “high.” THC binds with receptors in the brain that manage pain, mood, and hunger. That’s why THC can make you feel euphoric and impart the typical cannabis “high”.

However, CBD doesn’t cause that high. Instead, it binds to separate receptors in the brain linked to sleep, relaxation, and others. This is why CBD makes you feel more relaxed and calm rather than high. Understanding this difference is key to understanding why people who may not partake of marijuana, are eager to use CBD for their health.


What is CBD?

CBD, or cannabidiol, is a commonly found active ingredient in hemp. While CBD is an essential component of medical marijuana, it is extracted directly from the hemp plant, which is a cousin of the marijuana plant. While prized for its healing properties, it is non-psychoactive unlike its cannabis cousin.

What does CBD feel like?

The effects of CBD are subtle to moderate. It’s non-psychoactive, which means CBD won’t make you high or euphoric— however, it can give you a mild, relaxed  “calm” sensation. 

Can CBD be taken for pain relief?

CBD is often used to ease mild aches and pains and reduce soreness from muscle exertion, but research also suggests that CBD could aid in the relief of chronic pain. CBD creams are your best bet for quick and effective pain relief.

What CBD products can you use on your skin?

CBD topicals are any CBD products you can use on your skin: creams, lotions, balms, roll-ons, and salves. CBD lotions, creams, and balms are typically not edible and are intended to be applied directly to specific affected areas of the skin.

Can I take CBD for sleep issues?

CBD interacts with the endocannabinoid system, which is responsible for regulating sleep in the body. CBD oils and tinctures work best for promoting sleep. We suggest you do your own research and listen to your body for the best results.

How does CBD work for anxiety?

CBD helps reduce anxiety by targeting several independent mechanisms involved with hyperactivity in the nerves. CBD is known to boost GABA activity in the brain, which is responsible for calming down the brain. It acts like a brake for an overactive mind, slowing it down when it becomes anxious.

Will I fail a drug test after consuming CBD?

In most parts of the world, the psychoactive cannabinoid in cannabis plants (THC) is considered illegal. Drug tests searching for marijuana look for traces of THC. Because these tests are typically generic, looking for metabolites in the body from the breakdown of cannabinoids, there is a small chance the use of a CBD topical could cause a positive test.

However, CBD is completely non-psychoactive and legal in most countries. Therefore, it’s highly unlikely that a drug test will search for CBD content since there’s no reason to look for this compound since it’s not illegal. Topical application rather than ingestion also makes it unlikely that a CBD cream would trigger a false positive on most commercially used drug test kits.


With the large, and constantly growing, variety of CBD products available online, it can be quite a task to pick one best suited to your needs and budget. Very few products actually deliver what they advertise. There are even fewer that are reliable and safe in the long run.

It’s imperative to do your research and pick a product that’s best for you. These are some of the best CBD creams available on the market today:

Top Pick: CBDPure

Cost-effective: Populum

Decent choice: Xwerks

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